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NFL
BUF
NE
o43.5
+4
8:15PM • PREVIEW
PIT
ATL
o43
+1
1:00PM • PREVIEW
GB
CHI
o43.5
+4
1:00PM • PREVIEW
JAX
DET
o51.5
+1.5
1:00PM • PREVIEW
NYJ
MIN
o45.5
-3
1:00PM • PREVIEW
WAS
NYG
o40.5
+2.5
1:00PM • PREVIEW
TEN
PHI
o44.5
-5.5
1:00PM • PREVIEW
DEN
BAL
o38.5
-8.5
1:00PM • PREVIEW
CLE
HOU
o47
+7
1:00PM • PREVIEW
SEA
LAR
o41.5
+7.5
4:05PM • PREVIEW
MIA
SF
o46.5
-4
4:05PM • PREVIEW
KC
CIN
o52.5
+2
4:25PM • PREVIEW
LAC
LV
o50.5
+2
4:25PM • PREVIEW
IND
DAL
o43.5
-11
8:20PM • PREVIEW
NO
TB
o40
-3.5
8:15PM • PREVIEW

NFL Best Bets: Week 4 Odds, Previews, Predictions

Will Desvallees Sep 30th 11:40 AM EDT.

Let’s examine Week 4’s NFL lines and odds and pinpoint the best bets to wager on this week.

The first three weeks of the regular season have been highly contested. By the end of Week 3, only two teams remained undefeated: the Miami Dolphins and the Philadelphia Eagles. However, the Dolphins lost their first game of the season on Thursday Night Football to Joe Burrow and the Cincinnati Bengals last night. 

Week 4’s lines and betting odds for many games may seem closer than you might expect. For example, the Carolina Panthers are favored to beat the Cleveland Browns at home. After the Ravens and the Bills both lost to the Miami Dolphins in Week 2 and Week 3 respectively, the Bills are only three-point favorites to defeat the Ravens this weekend. 

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Let’s take a look at our Week 4 best bets! 

Please Note: These odds were updated at 11:00 AM EST. from FanDuel Sportsbook. 

Game: Minnesota Vikings at New Orleans Saints +3 (-104)

The Vikings and the Saints will be playing in the UK on Sunday morning. The Vikings are off to a better start than their opponents this season as they are tied with the Bears and the Packers for first place in the NFC North. The Saints started off the season with an impressive fourth quarter comeback victory after almost blowing the game to Marcus Mariota and the Atlanta Falcons. However, Jameis Winston and the Saints have been fundamentally unable to get any meaningful offense going on a consistent basis since the fourth quarter of Week 1. Additionally, there are some injury concerns for the Saints heading into Sunday. Jameis Winston is out as is star wide receiver Michael Thomas. Both Thomas and Jarvis Landry left Week 3’s matchup against the Panthers with injuries and did not practice this week. Still, the Saints have a deep receiving corps with Chris Olave and Tre’Quan Smith at the forefront (if Landry and Thomas are forced to miss time). Andy Dalton may fill in for the Saints though Taysom Hill will likely be sprinkled into the offensive game plan as well. 

The Vikings have one of the best receivers in the league in Justin Jefferson and Adam Thielen is a more than serviceable WR2. Not to mention, K.J. Osborn has really come on and Irv Smith is finally healthy at the tight end position for the Vikings. 

Both teams have star-caliber running backs in Dalvin Cook and Alvin Kamara who should suit up on Sunday. Ultimately, both teams would need to average 21 points of offense on Sunday which seems easily attainable. While the Saints’ offense has been a disaster over the last two weeks (and the season altogether) expect Jameis to go for at least a couple touchdowns on Sunday. The Vikings have so many playmakers that it’s hard to see them not scoring upwards of 28 points on Sunday despite New Orleans’ stout defense.

Bet: Over 41.5 Total Points (-108)

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Game: Chicago Bears at New York Giants -3 (-105)

The New York Giants are coming off of a rough Monday Night Football in Week 3. Daniel Jones and his receivers have failed to get going this season. Making matters worse, Sterling Shepard tore his ACL jogging downfield which leaves the G-Men with a massive hole to fill. Still, the Bears don’t have an impressive offense. Second-year quarterback Justin Fields is off to yet another unimpressive start. So far in 2022, Fields has completed just 51.1% of his passes for a meager 297 yards and two touchdowns compared to four interceptions. He is heading into Week 4 with an abysmal rating of 50.0. If Daniel Jones can connect with his pass-catchers just a little bit more on Sunday, the Giants have a good chance of winning by a touchdown or more at home after a difficult loss to their NFC East Rivals on Monday Night. 

The Pick: New York Giants -3 (-105)

Game: Buffalo Bills at Baltimore Ravens +3 (-110)

Both teams are heading into Sunday with a record of 2-1. Both of their losses were at the hands of Tua Tagovailoa and the Miami Dolphins. This AFC battle will questionably pit the two best quarterbacks in the league against one another. After the 21-19 loss to the Miami Dolphins, this game must feel like a must-win game for the Bills whose defense still looks like the best in the league. The Ravens’ running game will struggle against the Bills strong fron seven. Expect Josh Allen to have a huge bounce-back game after struggling against the Dolphins last weekend. Not to mention, Baltimore’s secondary is much more exploitable than Miami’s. Stefon Diggs was shadowed by Xaiver Howard in Week 3. The Ravens don’t have a cornerback who is capable of shutting down Diggs so fantasy owners should anticipate a huge outing from the first-round selection. This will be a high-scoring affair considering the two quarterbacks suiting up in this matchup but the Bills will defeat the Ravens by more than a field goal. 

The Pick: Buffalo Bills -3 (-110)

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Game: Seattle Seahawks at Detroit Lions -4 (-110)

While the Seattle Seahawks have two elite receivers in DK Metcalf and Tyler Lockett, their offense pales in comparison to the high-throttle Detroit Lions this season. Though the Lions have a 1-2 record and are in last place in the NFC North, they have been scoring big this season. In Week 1, the Lions tallied 35 points in a three-point loss to the undefeated Philadelphia Eagles. In Week 2, the Lions captured their first victory of the season, defeating the Washington Commanders 36-27. Finally in Week 3, they put up 24 points in a losing effort to the Minnesota Vikings. Detroit has been effective on offense by combining an unpredictable running game featuring D’Andre Swift and Jammall Williams with a solid passing game made possible by second-year WR Amon-Ra St. Brown. Even though Swift likely won’t be on the field for this game, Detroit proved last week that they can move the chains with J-Will and third-string running back Craig Reynolds

Seattle has very strong pass-catchers but Geno Smith is one of the worst starting quarterbacks in the league (despite a decent start to the season) and that backfield featuring Rashaad Penny and rooke Kenneth Walker hasn’t done much in 2022. Look for the Lions to move to 2-2 in Week 4 by beating Seattle by 5+ points.

The Pick: Detroit Lions -4.5 (-110)  

Game: Washington Commanders at Dallas Cowboys -3 (-110)

Despite Dak Prescott being out of the picture for the Dallas Cowboys, Cooper Rush has taken over at quarterback and he’s played a major role in helping the team win over the last two weeks. Carson Wentz and the Washington offense has done okay, but simply doesn’t have the talent the Cowboys’ does. Not to mention, this Washington defense is in a steep decline. A few years ago, they were legitimately the top defense in the entire NFL. Now, they are one of the most exploitable both in the rushing and the passing game. Look for Ezekil Elliott to break out for his best game of the season. And Dallas may be getting WR2 Michael Gallup back just in time for this matchup. With CeeDee Lamb, Michael Gallup, Noah Brown, and Jalen Tolbert, plus tight end Dalton Schultz, Rush has some really solid weapons surrounding him. Even Tony Pollard has looked great this season when filling in for Zeke. Add the home factor for Dallas and it seems like a no brainer that “America’s Team” will win by at least a field goal on Sunday.

The Pick: Dallas Cowboys -3 (-110)

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Game: Arizona Cardinals at Carolina Panthers -1.5 (-110)

The Panthers will not win two consecutive home games, especially not against the Arizona Cardinals. The 1-2 Cardinals have struggled this season despite winning an impressive 29-23 overtime victory over the Raiders in Week 2. Their two losses came at the hands of the Kansas City Chiefs (Week 1) and the Los Angeles Rams (Week 3), who simply are both much better teams than the Cards. 

Baker Mayfield of the Panthers hasn’t done much this season. He’s completed a career-low 51.9% of his passes for 550 yards, three touchdowns, and one interception this season. Mayfield completed less than 50% of his passes in each of the last two weeks. Mayfield has struggled to get the ball into his star wide receiver’s hands, D.J. Moore, and Chrsitian McCaffrey isn’t seeing nearly enough work in the short-passing game. This needs to change if Carolina wants to be competetive.

It’s crucial to recognize that Arizona started the season with an incredibly difficult schedule. With the exception of the Raiders who choked to the Cardinals late in Week 2, Arizona has had to play two of the strongest teams in the NFL within the first three Weeks. And all three of those teams made the postseason last year. While Arizona is playing on the road in Carolina, expect the Cardinals to bounce back against a weak team with a new quarterback who has been nothing but disappointing since becoming a Panther.

The Pick: Arizona Cardinals ML (-102)


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