Fantasy Football Week 2 Quarterback Start/Sit: Dak Prescott, Trevor Lawrence, and More

One week of football doesn't tell us a lot. Last year, the Raiders beat the Patriots in Week 1; Vegas then ended up with the top overall pick, while New England made a run to the Super Bowl. In the fantasy world, though, it's all we have to go on, so we have to ignore that it's a small sample and roll it up with everything else we know (or think we know) to make informed decisions.

Let's look at three quarterbacks to start and three to sit in Week 2 of the fantasy football season. Most stats are from NFL.com, and fantasy points and rankings are from FantasyPros.

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Start

Kyler Murray and Carson Wentz, Minnesota Vikings @ Chicago Bears

Let's start with an uncertain situation, as Murray suffered a concussion in the first quarter of Week 1, leaving it unknown if he will suit up in Week 2. The matchup makes it so that no matter who plays, the guy under center in Minnesota will have a bright outlook in fantasy.

Last season, the Bears allowed the fifth-most yards per pass attempt and the fifth-most fantasy points to quarterbacks. They kicked off 2026 by allowing Bryce Young to throw for 361 yards (on 9.8 per attempt) with three touchdowns while also letting him score on the ground. Young was QB3 in the first week; there's a big ceiling for whoever plays for the Vikings.

Murray is dangerous with his legs, making him an intriguing option every time he takes the field. Wentz doesn't run that much (though he was spry in his younger days), but either guy should also be able to take advantage through the air and put up numbers, especially if they have to throw to keep up with the Bears' offense. I love Murray this week if he plays, and I like Wentz if he's the guy.

Dak Prescott, Dallas Cowboys vs. Washington Commanders

Prescott wasn't great against the Giants in Week 1, throwing for 175 yards on a paltry 5.1 yards per attempt, though he did throw two touchdowns to go with an interception. I'm not ready to call the Giants a top defense by any means, but they do have a lot of talent on that side of the ball and could continue to be formidable.

Washington doesn't seem to present the same level of opponent, as they allowed the third-most yards per pass attempt and the third-most fantasy points to quarterbacks last season. While they added talent in the offseason, the Commanders let Jalen Hurts find plenty of efficiency last week, as he averaged 8.1 yards per attempt and threw three touchdowns.

The Cowboys' offense will have better games than they did in the Sunday night opener, and this could be a chance to get things back on track. Prescott is a very middling fantasy player, but the matchup is on his side this week to make fantasy owners much happier than they were on Sunday night with his performance.

Brock Purdy, San Francisco 49ers vs. Miami Dolphins

Purdy had a tougher matchup in Week 1 against the Rams, and while his efficiency suffered (205 yards on 6.0 per attempt), he did find the end zone three times, putting him at QB10 for the week. Even with a new cast of wide receivers and injuries already building up again, I trust San Francisco's offense under coach Kyle Shanahan, and Purdy has shown that he can put up numbers in the right matchups.

This appears to be one of those matchups. Last season, the Dolphins gave up the seventh-most yards per pass attempt and 11th-most fantasy points per game to quarterbacks. It's not a stretch to say that Miami has one of the most barren rosters in the league, and there will be games in which the opponent has their way with the Dolphins; this could be one of those weeks.

Kirk Cousins didn't have a great performance against Miami last week, averaging just 5.3 yards per attempt, but he's another guy who found the end zone three times. The Raiders, as much as they've upgraded their talent the past few years, aren't the 49ers by any stretch, especially with Brock Bowers out, and Purdy and Co. have a better chance of putting together both volume and efficiency.

Sit

Jacoby Brissett, Arizona Cardinals vs. Seattle Seahawks

The Seahawks spoiled the opener for fans a bit, losing their own starting quarterback to injury after one series and then shutting down their opponent, helping lead to a 13-10 game. That defensive prowess isn't new; on the way to the Super Bowl last year, Seattle allowed the fewest yards per pass attempt and the 10th-fewest fantasy points to QBs. I'm not looking to test them often with anyone but the best players.

Brissett had strong volume last year after taking over for the injured Murray in Arizona. From Week 6 through the end of the season, Brissett was fantasy QB6. He was only average from an efficiency standpoint, but Brissett threw the ball more than 40 times per game in the 12 contests he started.

He continued that trend in Week 1 in a seemingly tough matchup against the Chargers, throwing the ball 37 times for 277 yards and a touchdown. Brissett started one game against Seattle last season and had 258 yards and two touchdowns on 44 attempts; a similar game is possible. As I said above, though, I'm not keen on testing the Seahawks and can't suggest Brissett as more than a middling option in this one.

Daniel Jones, Indianapolis Colts @ Kansas City Chiefs

While we give more attention to Kansas City's offense, it was their defense that was the driving force behind some of their most successful seasons recently. The Chiefs were a little better than average in both yards per pass attempt and fantasy points given up to QBs last year, finding success even in a down year.

KC was very stingy in Week 1, holding Bo Nix to 131 yards on 4.7 per attempt. Jones similarly struggled against Baltimore in the opening game, gaining 166 on just 5.4 per attempt.

Jones is coming off his best season, though it ended early due to a torn Achilles. It's possible that he is still working his way back and might not be at full speed, especially when it comes to running the ball. After the way he struggled in Week 1 and with a potentially tough matchup in this one, I'm leaving him on the bench until we see something more in line with what we saw in 2025.

Trevor Lawrence, Jacksonville Jaguars @ Denver Broncos

Lawrence and the Jags were fantastic in Week 1, winning 34-10 in a game in which they led for more than 53 minutes. Lawrence had 245 yards on 10.7 per attempt with four touchdowns. That comes after a strong 2025 in which he was QB4; it's tough to expect poor play.

The Broncos have been a strong defensive team the past few years, and though Kansas City found success against Denver on Monday night, most of that damage came on the ground. Patrick Mahomes was OK, finishing with 184 yards on 6.8 per attempt with two touchdowns and an interception while the team gained 220 rushing yards.

I'm not necessarily down on Lawrence here, but I'm also not excited about testing Denver's defense. They were still fine in a rough Week 1, and they have plenty of talent on that side of the ball to make things tough on Jacksonville's passing game. Lawrence is still worth considering, but beware that there could be a low floor involved.