Joe Flacco on his first possession today: 7/7 75 yards 1 TD 150.9 passer rating Elite. pic.x.com/3HwHEDFIPr

No surprise after Anthony Richardson was downgraded to doubtful, but it's considered "very likely" that Colts QB Joe Flacco will start today vs. the Jaguars, per source.

Colts OT Will Fries fractured his lower leg and will undergo surgery tonight in a Jacksonville hospital, per source.

The #Jaguars have given up 14 unanswered to the #Colts and this game is tied. Joe Flacco and Alec Pierce are going crazy. pic.x.com/BSowCREbWE

JOE FLACCO GOT WHEELS

@NFL_DovKleiman: Flacco to Mo Alie-Cox on 3rd and 15. TOUCHDOWN. https://t.co/5TCGyfIb0R https://t.co/qrAMg5MihM

Jacksonville and Indianapolis’ Week 5, AFC South matchup in Jacksonville will be without a lot of offensive star power.

The Jaguars and Colts officially ruled a combined six starters out in the hours before kickoff Sunday, including four key offensive contributors, tight end Evan Engram on Jacksonville’s side and quarterback Anthony Richardson, running back Jonathan Taylor and center Ryan Kelly on Indianapolis’.

Find Jacksonville and Indianapolis’ inactive lists for Week 5 below.

Analysis: Jaguars starting tight end Evan Engram (hamstring) will miss his fourth consecutive game, despite his return to practice in a limited capacity this week. Brenton Strange will likely start in his place

The Indianapolis Colts will be without a number of key starters against the Jacksonville Jaguars, but some positive news is that both Braden Smith and Sam Womack will be available.

Smith was listed as questionable on Friday after not practicing on Wednesday or Friday this past week with a knee injury. Womack, meanwhile, practiced all week but was added to the injury report on Saturday with an illness and was listed as questionable at the time.

Smith has missed some practice time over the last few weeks but has been available on Sundays. Over the last three games, Smith has allowed only two pressures and one sack, which includes matching up with Pittsburgh’s TJ Watt this past Sunday