Mitchell is expected to head the 49ers backfield Sunday in Philadelphia, Ian Rapoport of NFL Network reports.

Mitchell stepped in for an injured Raheem Mostert in Week 1 at Detroit and ripped off 104 yards and one touchdown on 19 carries. With Mostert on the shelf for the rest of the season following knee surgery, Mitchell has assumed the No. 1 spot on the depth chart, but he'll have to contend with JaMycal Hasty and third-round rookie Trey Sermon, the latter of whom was inactive last Sunday. Mitchell himself was selected in the sixth round of the 2021 NFL Draft, so his sudden rise seemingly has him on pace to be featured in coach Kyle Shanahan's scheme.

Micah Parsons played defensive end for the first time since high school… He had 8 pressures (most by a rookie since Nick Bosa in 2019) 🤯 pic.twitter.com/ZIssNNoDFB

Veteran CB Josh Norman, who signed with the 49ers less than two weeks ago, is expected to start today at Philadelphia against the Eagles, per source.

Are you going to be a little sore tomorrow? Jimmy Garoppolo: "From what?"

Officially active: ▪️Gabe Davis ▪️Keelan Cole ▪️Jonnu Smith ▪️Trey Sermon ▪️Michael Pittman ▪️Zack Moss ▪️Eric Fisher Officially inactive: ▪️Rhamondre Stevenson ▪️Marshon Lattimore ▪️Jamison Crowder

First NFL catch is a TD for Jauan Jennings! 🙌 📺 #SFvsPHI on FOX pic.twitter.com/FRuu0EwiPe

Trey Lance szn can't get here soon enough. Jimmy Garoppolo's average depth of target was 3.97 yards today 🤢 Air yard leaders: 48 — Deebo Samuel 36 — Trent Sherfield 26 — Brandon Aiyuk -6 — George Kittle 🤮

Brandon Aiyuk didn't see any targets in Week 1, but made his lone catch in Week 2 count in the 49ers' win over the Eagles.

It wasn't pretty, but the #49ers pulled off the 17-11 victory over the Eagles with notable performances from Deebo Samuel and Nick Bosa. Takeaways from #SFvsPHI 👇

The #49ers are optimistic that DE Arik Armstead (abductor) and DT Javon Kinlaw (knee) will play today vs. #Eagles, per me and @MikeGarafolo, provided warmups go well.

Shanahan lauds Deommodore Lenoir for making adjustments and locking Philly down after giving up the big one

Javon Kinlaw already making a huge difference for the 49ers. He was immovable on that first drive. Just a pillar of granite

Obvious that recording such a physical victory early in the season is very important to the 49ers. Fred Warner: "The hard ones are the ones that mean the most."

49ers will receive to start the game. The Trenton Cannon era is about to take off.

Robbie Gould boots a 46-yard FG to give #49ers a 17-3 lead. That caps a fun week for him. He shot a 73 on his day off at The Greenbrier.

Hat tip to DeMeco Ryans. He had the 49ers VERY prepared on that fourth down

To those who thought that one Trey Lance TD pass in Week 1 of the preseason somehow changed the way Shanahan thought about the QB position: That was what a real NFL game looked like

49ers' RB attrition is wild. Wilson, Mostert, Sermon, Mitchell, Hasty all now hurt. TBD on the Week 3 status of the final three. What does SF do this week? Depends on health developments, but seems there's a good chance they start with a Kerryon Johnson practice squad call-up

CB Emmanuel Moseley in pads and helmet doing full-field sprints. He's unlikely to play today (doubtful, knee) but next week vs. GB seems like safe bet.

Trent Sherfield dropped the punt as a gunner, but Trenton Cannon still downs at the 2-yard line.

Sermon's first carry results in a huge hit. He's now sitting up but 49ers will finish this game with one tailback, JaMycal Hasty.

#SFvsPHI @DignityHealth Injury Update: DL Kevin Givens (ankle) is questionable to return.

#49ers open a game w/ 3 straight 3 and outs for the 1st time in the Kyle Shanahan era. They last did it 11/13/16 vs Cardinals w/ Chip Kelly as coach. Haven't done 4 straight since 9/27/09

Kyle Juszczyk seemed to be moving well after the game. We'll see what Shanahan says about the injuries. twitter.com/mattbarrows/st…

Alex Mack: "They're just a very talented front… They showed a different front than they had previously, and it took a while." Feeling-out process confirmed

First day for full stadium since January '20 — the only postseason game of C. Wentz's career. Much has changed since. First 49ers visit since October '17, before they traded for J. Garoppolo. Much has changed since. Nate Sudfeld is on the field pregame. Some things don't change pic.twitter.com/cqd0EWGSkk